Assay Detail
Binding
CHEMBL708305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirus
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.49 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347537 | — | — | 1 | 6.98 |
| CHEMBL153843 | — | — | 1 | 6.63 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 6.46 |
| CHEMBL75232 | — | — | 1 | 6.21 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347537 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL153843 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL75232 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 660.0 | nM | 6.18 |