Assay Detail
Functional
CHEMBL708323
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Compound was tested for its inhibition of HIV-1 induced focus formation in MAGI-CCR5 cells in strains like NL4-3K103N
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.63 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319139 | — | — | 1 | 7.40 |
| CHEMBL141966 | — | — | 1 | 6.60 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319139 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL141966 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL35033 | EMIVIRINE | EC50 | = | 1260.0 | nM | 5.90 |