Assay Detail
Functional
CHEMBL708386
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 P24 production.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Three-dimensional structure-activity analysis of a series of porphyrin derivatives with anti-HIV-1 activity targeted to the V3 loop of the gp120 envelope glycoprotein of the human immunodeficiency virus type 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.20 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275772 | — | — | 1 | 6.21 |
| CHEMBL275968 | — | — | 1 | 6.20 |
| CHEMBL12947 | — | — | 1 | 6.12 |
| CHEMBL275907 | — | — | 1 | 6.11 |
| CHEMBL275908 | — | — | 1 | 5.99 |
| CHEMBL273179 | — | — | 1 | 5.97 |
| CHEMBL429192 | — | — | 1 | 5.93 |
| CHEMBL1325592 | PROTOPORPHYRIN | -1.0 | 1 | 5.66 |
| CHEMBL406782 | — | — | 1 | 5.52 |
| CHEMBL273300 | — | — | 1 | 5.25 |
| CHEMBL273985 | — | — | 1 | 5.21 |
| CHEMBL429013 | — | — | 1 | 5.04 |
| CHEMBL430288 | — | — | 1 | 4.97 |
| CHEMBL12645 | — | — | 1 | 4.91 |
| CHEMBL276179 | — | — | 1 | 4.85 |
| CHEMBL267647 | — | — | 1 | 4.83 |
| CHEMBL275087 | — | — | 1 | 4.68 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | — | 1 | 4.55 |
| CHEMBL1200662 | HEMIN | 3.0 | 1 | 4.45 |
| CHEMBL430103 | — | — | 1 | 4.36 |
| CHEMBL12659 | — | — | 1 | 4.26 |
| CHEMBL274126 | — | — | 1 | 4.26 |
| CHEMBL12467 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275772 | — | EC50 | = | 612.0 | nM | 6.21 |
| CHEMBL275968 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL12947 | — | EC50 | = | 758.0 | nM | 6.12 |
| CHEMBL275907 | — | EC50 | = | 774.0 | nM | 6.11 |
| CHEMBL275908 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL273179 | — | EC50 | = | 1075.0 | nM | 5.97 |
| CHEMBL429192 | — | EC50 | = | 1174.0 | nM | 5.93 |
| CHEMBL1325592 | PROTOPORPHYRIN | EC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL406782 | — | EC50 | = | 3018.0 | nM | 5.52 |
| CHEMBL273300 | — | EC50 | = | 5589.0 | nM | 5.25 |
| CHEMBL273985 | — | EC50 | = | 6163.0 | nM | 5.21 |
| CHEMBL429013 | — | EC50 | = | 9037.0 | nM | 5.04 |
| CHEMBL430288 | — | EC50 | = | 10724.0 | nM | 4.97 |
| CHEMBL12645 | — | EC50 | = | 12276.0 | nM | 4.91 |
| CHEMBL276179 | — | EC50 | = | 14057.0 | nM | 4.85 |
| CHEMBL267647 | — | EC50 | = | 14659.0 | nM | 4.83 |
| CHEMBL275087 | — | EC50 | = | 20686.0 | nM | 4.68 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | EC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL1200662 | HEMIN | EC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL430103 | — | EC50 | = | 43317.0 | nM | 4.36 |
| CHEMBL12659 | — | EC50 | = | 54411.0 | nM | 4.26 |
| CHEMBL274126 | — | EC50 | = | 54708.0 | nM | 4.26 |
| CHEMBL12467 | — | EC50 | = | 67874.0 | nM | 4.17 |