Assay Detail
Binding
CHEMBL708405
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Binding affinity for Leukotriene B4 (LTB4) receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Second-generation leukotriene B4 receptor antagonists related to SC-41930: heterocyclic replacement of the methyl ketone pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.49 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355503 | — | — | 1 | 7.60 |
| CHEMBL436047 | — | — | 1 | 7.58 |
| CHEMBL99099 | — | — | 1 | 7.38 |
| CHEMBL168944 | — | — | 1 | 7.03 |
| CHEMBL168658 | — | — | 1 | 7.00 |
| CHEMBL166699 | — | — | 1 | 6.85 |
| CHEMBL169120 | — | — | 1 | 6.50 |
| CHEMBL14823 | SC-41390 | — | 1 | 6.50 |
| CHEMBL352863 | — | — | 1 | 6.28 |
| CHEMBL169683 | — | — | 1 | 6.21 |
| CHEMBL172628 | — | — | 1 | 6.11 |
| CHEMBL169722 | — | — | 1 | 6.05 |
| CHEMBL169446 | — | — | 1 | 5.96 |
| CHEMBL169835 | — | — | 1 | 5.94 |
| CHEMBL171780 | — | — | 1 | 5.55 |
| CHEMBL169246 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355503 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL436047 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL99099 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL168944 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL168658 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL166699 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL169120 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL14823 | SC-41390 | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL352863 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL169683 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL172628 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL169722 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL169446 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL169835 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL171780 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL169246 | — | IC50 | = | 5800.0 | nM | 5.24 |