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Assay Detail

CHEMBL708406

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Leukotriene B4 receptor 1 (CHEMBL3911)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Second-generation leukotriene B4 receptor antagonists related to SC-41930: heterocyclic replacement of the methyl ketone pharmacophore.
Penning TD, Djuric SW, Miyashiro JM, Yu S, Snyder JP, Spangler D, Anglin CP, Fretland DJ, Kachur JF, Keith RH.
J Med Chem (1995) 38 : 858 -868
PubMed 7699700 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.37 7.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL14823 SC-41390 1 7.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL14823 SC-41390 IC50 = 43.0 nM 7.37