Assay Detail
Functional
CHEMBL708808
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Concentration of compound required to inhibit the cellular protein biosynthesis by 50%
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
6-[(aminoalkyl)amino]-substituted 7H-benzo[e]perimidin-7-ones as novel antineoplastic agents. Synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.43 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334256 | — | — | 1 | 6.69 |
| CHEMBL424265 | — | — | 1 | 6.57 |
| CHEMBL49442 | AMETANTRONE | 2.0 | 1 | 6.56 |
| CHEMBL336632 | — | — | 1 | 6.53 |
| CHEMBL133464 | — | — | 1 | 6.42 |
| CHEMBL129994 | — | — | 1 | 6.34 |
| CHEMBL130776 | — | — | 1 | 6.26 |
| CHEMBL134021 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334256 | — | EC50 | = | 203.0 | nM | 6.69 |
| CHEMBL424265 | — | EC50 | = | 268.0 | nM | 6.57 |
| CHEMBL49442 | AMETANTRONE | EC50 | = | 275.0 | nM | 6.56 |
| CHEMBL336632 | — | EC50 | = | 296.0 | nM | 6.53 |
| CHEMBL133464 | — | EC50 | = | 379.0 | nM | 6.42 |
| CHEMBL129994 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL130776 | — | EC50 | = | 546.0 | nM | 6.26 |
| CHEMBL134021 | — | EC50 | = | 945.0 | nM | 6.03 |