Assay Detail
Binding
CHEMBL708865
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Ability to antagonize LTD4 receptors isolated from guinea pig lung membranes
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Development of new chromanol antagonists of leukotriene D4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.07 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300701 | — | — | 2 | 9.15 |
| CHEMBL21333 | PRANLUKAST | 4.0 | 1 | 9.10 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | 8.70 |
| CHEMBL52102 | — | — | 1 | 8.52 |
| CHEMBL442150 | — | — | 1 | 7.85 |
| CHEMBL415954 | — | — | 1 | 7.72 |
| CHEMBL299779 | — | — | 1 | 7.57 |
| CHEMBL50399 | — | — | 1 | 7.04 |
| CHEMBL297906 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300701 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL21333 | PRANLUKAST | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL300701 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL603 | ZAFIRLUKAST | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL52102 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL442150 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL415954 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL299779 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL50399 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL297906 | — | Ki | = | 434.0 | nM | 6.36 |