Assay Detail
Functional
CHEMBL708942
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In vitro inhibition of L1210 growth after 48 hours.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antiproliferative properties of polyamine analogues: a structure-activity study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.57 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77101 | DIETHYLHOMOSPERMINE | 1.0 | 1 | 6.70 |
| CHEMBL37795 | — | — | 1 | 6.52 |
| CHEMBL84121 | — | — | 1 | 6.52 |
| CHEMBL83086 | — | — | 1 | 6.40 |
| CHEMBL83336 | — | — | 1 | 6.00 |
| CHEMBL18111 | — | — | 1 | 5.52 |
| CHEMBL83536 | — | — | 1 | 4.85 |
| CHEMBL79550 | — | — | 1 | 4.70 |
| CHEMBL18794 | BIS(ETHYL)SPERMINE | — | 1 | 4.52 |
| CHEMBL82888 | — | — | 1 | 4.00 |
| CHEMBL421337 | — | — | 1 | - |
| CHEMBL79699 | — | — | 1 | - |
| CHEMBL44083 | BIS(ETHYL)NORSPERMINE | — | 1 | - |
| CHEMBL310689 | — | — | 1 | - |
| CHEMBL81415 | — | — | 1 | - |
| CHEMBL81361 | — | — | 1 | - |
| CHEMBL274477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77101 | DIETHYLHOMOSPERMINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL37795 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL84121 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL83086 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL83336 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL18111 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL83536 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL79550 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL18794 | BIS(ETHYL)SPERMINE | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL82888 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL421337 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL79699 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44083 | BIS(ETHYL)NORSPERMINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL310689 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL81415 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL81361 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL274477 | — | IC50 | > | 100000.0 | nM | - |