Assay Detail
Functional
CHEMBL708991
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Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
1-[(omega-aminoalkyl)amino]-4-[N-(omega-aminoalkyl)carbamoyl]-9-oxo-9, 10-dihydroacridines as intercalating cytotoxic agents: synthesis, DNA binding, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.16 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 10.40 |
| CHEMBL104900 | — | — | 1 | 7.36 |
| CHEMBL540070 | — | — | 1 | 7.30 |
| CHEMBL104004 | — | — | 1 | 6.85 |
| CHEMBL105362 | — | — | 1 | 6.39 |
| CHEMBL340343 | — | — | 1 | 6.36 |
| CHEMBL124605 | — | — | 1 | 6.36 |
| CHEMBL327096 | — | — | 1 | 6.34 |
| CHEMBL123024 | — | — | 1 | 6.28 |
| CHEMBL125371 | — | — | 1 | 5.92 |
| CHEMBL126010 | — | — | 1 | 5.78 |
| CHEMBL125475 | — | — | 1 | 5.77 |
| CHEMBL55400 | PROFLAVINE | 2.0 | 1 | 5.57 |
| CHEMBL125180 | — | — | 1 | 5.48 |
| CHEMBL121823 | — | — | 1 | 5.40 |
| CHEMBL124025 | DIMINAZEN ACETURATE | — | 1 | 4.50 |
| CHEMBL122057 | — | — | 1 | 4.46 |
| CHEMBL39677 | ACRIDINE | 2.0 | 1 | 4.35 |
| CHEMBL436589 | ACRIDONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL104900 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL540070 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL104004 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL105362 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL340343 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL124605 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL327096 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL123024 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL125371 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL126010 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL125475 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL55400 | PROFLAVINE | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL125180 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL121823 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL124025 | DIMINAZEN ACETURATE | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL122057 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL39677 | ACRIDINE | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL436589 | ACRIDONE | IC50 | > | 100000.0 | nM | - |