Compound Detail
CHEMBL39677
ACRIDINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL39677 |
| Name | ACRIDINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | DZBUGLKDJFMEHC-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
20
Publications
2
Known Names
2
Indications
1
Mechanisms
Molecular Properties
179.2
MW (Da)
3.39
ALogP
1
HBA
0
HBD
12.9
PSA (Ų)
0.48
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| DNA disrupting agent | DISRUPTING AGENT | DNA | ✓ | ✓ |
Indications
Central Nervous System Neoplasms Lung Neoplasms
Activity Summary
IC50 3 meas. best 5.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acetylcholinesterase CHEMBL220 | IC50 | 5.17 | 5.17 | 6840.0 | 1 |
| L1210 CHEMBL386 | IC50 | 4.35 | 4.35 | 45000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | IC50 | = | 6840.0 | nM | 5.17 | Inhibition of recombinant human C-terminal 6His-tagged AChE (Glu32 to Leu614 res... | 32151835 |
| L1210 | IC50 | = | 45000.0 | nM | 4.35 | Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug c... | 9371240 |
| L1210 | IC50 | = | 45000.0 | nM | 4.35 | Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 l... | 7658436 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6167716 | 10.1021/jm00135a006 | ADMET | 8 |
| 7658436 | 10.1021/jm00018a009 | Nucleic Acid | 5 |
| 9371240 | 10.1021/jm970114u | Calf thymus DNA | 3 |
| 7658436 | 10.1021/jm00018a009 | Calf thymus DNA | 3 |
| 19445516 | 10.1021/jm9000659 | Nucleic Acid | 3 |
| 11754587 | 10.1021/jm010289a | No relevant target | 2 |
| 9371240 | 10.1021/jm970114u | Nucleic Acid | 2 |
| 1271403 | 10.1021/jm00227a008 | No relevant target | 2 |
| 32151835 | 10.1016/j.ejmech.2020.112193 | Acetylcholinesterase | 1 |
| 27998679 | 10.1016/j.bmcl.2016.12.011 | DNA topoisomerase 2-alpha | 1 |
| 23395656 | 10.1016/j.bmcl.2013.01.022 | DNA | 1 |
| 19144451 | 10.1016/j.ejmech.2008.12.003 | 5-hydroxytryptamine receptor 3A | 1 |
| 19056282 | 10.1016/j.bmc.2008.11.040 | ADMET | 1 |
| 17300161 | 10.1021/jm0611105 | ADMET | 1 |
| 17300161 | 10.1021/jm0611105 | No relevant target | 1 |
| 6167716 | 10.1021/jm00135a006 | No relevant target | 1 |
| 7658436 | 10.1021/jm00018a009 | A2780 | 1 |
| 7658436 | 10.1021/jm00018a009 | L1210 | 1 |
| 9371240 | 10.1021/jm970114u | A2780 | 1 |
| 9371240 | 10.1021/jm970114u | L1210 | 1 |
Data from ChEMBL 36 via Core Engine