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Assay Detail

CHEMBL708986

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Novel acridine-triazenes as prototype combilexins: synthesis, DNA binding, and biological activity.
McConnaughie AW, Jenkins TC.
J Med Chem (1995) 38 : 3488 -3501
PubMed 7658436 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.87 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL117847 1 5.70
CHEMBL55400 PROFLAVINE 2.0 1 5.57
CHEMBL119468 1 5.52
CHEMBL324385 1 5.50
CHEMBL440518 1 5.47
CHEMBL115683 1 5.21
CHEMBL330968 1 4.55
CHEMBL35241 DIMINAZENE 2.0 1 4.50
CHEMBL117845 1 4.50
CHEMBL39677 ACRIDINE 2.0 1 4.35
CHEMBL119312 1 4.18
CHEMBL324037 1 4.17
CHEMBL332209 1 4.10
CHEMBL119715 1 -
CHEMBL116034 1 -
CHEMBL117980 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL117847 IC50 = 2000.0 nM 5.70
CHEMBL55400 PROFLAVINE IC50 = 2700.0 nM 5.57
CHEMBL119468 IC50 = 3000.0 nM 5.52
CHEMBL324385 IC50 = 3200.0 nM 5.50
CHEMBL440518 IC50 = 3400.0 nM 5.47
CHEMBL115683 IC50 = 6200.0 nM 5.21
CHEMBL330968 IC50 = 28000.0 nM 4.55
CHEMBL35241 DIMINAZENE IC50 = 32000.0 nM 4.50
CHEMBL117845 IC50 = 32000.0 nM 4.50
CHEMBL39677 ACRIDINE IC50 = 45000.0 nM 4.35
CHEMBL119312 IC50 = 66000.0 nM 4.18
CHEMBL324037 IC50 = 67000.0 nM 4.17
CHEMBL332209 IC50 = 80000.0 nM 4.10
CHEMBL119715 IC50 > 100000.0 nM -
CHEMBL116034 IC50 > 100000.0 nM -
CHEMBL117980 IC50 > 100000.0 nM -