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Assay Detail

CHEMBL709095

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Matrix Metallo Proteinase-1 (MMP-1)
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Interstitial collagenase (CHEMBL332)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of MMP-1: an examination of P1 C gem-disubstitution in the succinamide hydroxamate series
Robinson RP, Ragan JA, Cronin BJ, Donahue KM, Lopresti-Morrow LL, Mitchell PG, Reeves LM, Yocum SA
Bioorg Med Chem Lett (1996) 6 : 1719 -1724
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.28 8.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL45483 1 8.72
CHEMBL48226 1 7.40
CHEMBL295392 1 6.82
CHEMBL296142 1 6.34
CHEMBL433479 1 6.24
CHEMBL49833 1 6.11
CHEMBL295257 2 6.10
CHEMBL299812 1 5.55
CHEMBL46030 1 5.42
CHEMBL45676 1 4.76
CHEMBL300888 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL45483 IC50 = 1.9 nM 8.72
CHEMBL48226 IC50 = 40.0 nM 7.40
CHEMBL295392 IC50 = 150.0 nM 6.82
CHEMBL296142 IC50 = 460.0 nM 6.34
CHEMBL433479 IC50 = 570.0 nM 6.24
CHEMBL49833 IC50 = 770.0 nM 6.11
CHEMBL295257 IC50 = 800.0 nM 6.10
CHEMBL295257 IC50 = 2200.0 nM 5.66
CHEMBL299812 IC50 = 2800.0 nM 5.55
CHEMBL46030 IC50 = 3800.0 nM 5.42
CHEMBL45676 IC50 = 17500.0 nM 4.76
CHEMBL300888 IC50 > 30000.0 nM -