Assay Detail
Functional
CHEMBL709131
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Evaluated in vitro for antiproliferative activity against MCF-7 cell lines model of hormone dependent breast cancer
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel cyanoguanidines with potent oral antitumour activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.69 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104271 | — | — | 1 | 8.96 |
| CHEMBL104069 | — | — | 1 | 8.72 |
| CHEMBL105334 | — | — | 1 | 8.42 |
| CHEMBL420103 | — | — | 1 | 8.36 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.31 |
| CHEMBL105579 | — | — | 1 | 8.20 |
| CHEMBL320669 | — | — | 1 | 8.06 |
| CHEMBL316583 | — | — | 1 | 7.85 |
| CHEMBL104830 | — | — | 1 | 7.52 |
| CHEMBL323553 | — | — | 1 | 7.51 |
| CHEMBL17289 | CHS-828 | 1.0 | 1 | 7.51 |
| CHEMBL104407 | — | — | 1 | 7.43 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.41 |
| CHEMBL104254 | — | — | 1 | 7.38 |
| CHEMBL419732 | — | — | 1 | 7.28 |
| CHEMBL104607 | — | — | 1 | 7.27 |
| CHEMBL106064 | — | — | 1 | 7.25 |
| CHEMBL104608 | — | — | 1 | 6.92 |
| CHEMBL322225 | — | — | 1 | 6.82 |
| CHEMBL321953 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104271 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL104069 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL105334 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL420103 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL105579 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL320669 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL316583 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL104830 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL323553 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL17289 | CHS-828 | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL104407 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL104254 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL419732 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL104607 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL106064 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL104608 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL322225 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL321953 | — | IC50 | = | 230.0 | nM | 6.64 |