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Compound Detail

CHEMBL322225

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N#CN(C(=N)NCCCCCOc1ccccc1)c1ccncc1

Basic Information

ChEMBL ID CHEMBL322225
Phase Preclinical
Structure Type MOL
InChI Key FJZCMMCVSNUIEO-UHFFFAOYSA-N
7
Targets
7
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

323.4
MW (Da)
3.14
ALogP
4
HBA
2
HBD
85.0
PSA (Ų)
0.26
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H21N5O
MW 323.40
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -0.61

Activity Summary

IC50 7 meas. best 7.36

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NSCLC
CHEMBL612554
IC50 7.36 7.36 44.0 1
MCF7
CHEMBL387
IC50 6.82 6.82 150.0 1
NCI-H460
CHEMBL396
IC50 6.57 6.57 270.0 1
Lewis lung carcinoma cell line
CHEMBL614088
IC50 6.52 6.52 300.0 1
B16
CHEMBL381
IC50 6.28 6.28 530.0 1
WALKER
CHEMBL613532
IC50 6.21 6.21 610.0 1
YOSHIDA
CHEMBL612816
IC50 6.18 6.18 660.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(97)10152-4 NSCLC 1
- 10.1016/S0960-894X(97)10152-4 MCF7 1
- 10.1016/S0960-894X(97)10152-4 NCI-H460 1
- 10.1016/S0960-894X(97)10152-4 B16 1
- 10.1016/S0960-894X(97)10152-4 Lewis lung carcinoma cell line 1
- 10.1016/S0960-894X(97)10152-4 YOSHIDA 1
- 10.1016/S0960-894X(97)10152-4 WALKER 1
- 10.1016/S0960-894X(97)10152-4 NON-PROTEIN TARGET 1

Data from ChEMBL 36 via Core Engine