Assay Detail
Functional
CHEMBL748624
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Evaluated in vitro for antiproliferative activity against NIC-H460 cell lines derived from large cell carcinoma of the lung
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel cyanoguanidines with potent oral antitumour activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.22 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 8.46 |
| CHEMBL104069 | — | — | 1 | 8.24 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.15 |
| CHEMBL420103 | — | — | 1 | 7.89 |
| CHEMBL104271 | — | — | 1 | 7.68 |
| CHEMBL316583 | — | — | 1 | 7.57 |
| CHEMBL104407 | — | — | 1 | 7.43 |
| CHEMBL105334 | — | — | 1 | 7.42 |
| CHEMBL105579 | — | — | 1 | 7.39 |
| CHEMBL17289 | CHS-828 | 1.0 | 1 | 7.30 |
| CHEMBL104830 | — | — | 1 | 7.28 |
| CHEMBL320669 | — | — | 1 | 7.23 |
| CHEMBL106064 | — | — | 1 | 7.16 |
| CHEMBL323553 | — | — | 1 | 7.13 |
| CHEMBL322225 | — | — | 1 | 6.57 |
| CHEMBL104254 | — | — | 1 | 6.44 |
| CHEMBL104607 | — | — | 1 | 6.32 |
| CHEMBL321953 | — | — | 1 | 6.28 |
| CHEMBL104608 | — | — | 1 | 6.23 |
| CHEMBL419732 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL104069 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL420103 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL104271 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL316583 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL104407 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL105334 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL105579 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL17289 | CHS-828 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL104830 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL320669 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL106064 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL323553 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL322225 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL104254 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL104607 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL321953 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL104608 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL419732 | — | IC50 | = | 590.0 | nM | 6.23 |