Assay Detail
Functional
CHEMBL711225
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In vitro antiproliferative activity against Lewis cell lines
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Lewis lung carcinoma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel cyanoguanidines with potent oral antitumour activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.80 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.21 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.21 |
| CHEMBL322225 | — | — | 1 | 6.52 |
| CHEMBL17289 | CHS-828 | 1.0 | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL322225 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL17289 | CHS-828 | IC50 | = | 560.0 | nM | 6.25 |