Assay Detail
Binding
CHEMBL709166
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Binding affinity against LTB4 receptor in guinea pig membrane
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Acid unit modifications of 1,2,4,5-substituted hydroxyacetophenones and the effect on in vitro and in vivo LTB4 receptor antagonism
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.79 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15648 | — | — | 1 | 8.30 |
| CHEMBL15559 | — | — | 1 | 7.99 |
| CHEMBL15817 | — | — | 1 | 7.81 |
| CHEMBL15295 | — | — | 1 | 7.81 |
| CHEMBL15299 | — | — | 1 | 7.73 |
| CHEMBL15766 | LY-255283 | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15648 | — | Ki | = | 4.96 | nM | 8.30 |
| CHEMBL15559 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL15817 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL15295 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL15299 | — | Ki | = | 18.5 | nM | 7.73 |
| CHEMBL15766 | LY-255283 | Ki | = | 77.9 | nM | 7.11 |