Assay Detail
Binding
CHEMBL709167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacologic activity of hydroxyacetophenone-substituted benzophenone/xanthone leukotriene B4 receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.96 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65061 | LEUKOTRIENE_B4 | — | 1 | 9.92 |
| CHEMBL292768 | — | — | 1 | 8.92 |
| CHEMBL60881 | — | — | 1 | 8.17 |
| CHEMBL49302 | — | — | 1 | 8.11 |
| CHEMBL49210 | — | — | 1 | 7.35 |
| CHEMBL15766 | LY-255283 | — | 1 | 7.11 |
| CHEMBL58534 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65061 | LEUKOTRIENE_B4 | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL292768 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL60881 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL49302 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL49210 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL15766 | LY-255283 | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL58534 | — | Ki | = | 751.0 | nM | 6.12 |