Assay Detail
Binding
CHEMBL709168
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LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structural analogues of LY292728, a highly potent xanthone dicarboxylic acid leukotriene B4 receptor antagonist: spatial positioning of the secondary acid group
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.63 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292782 | — | — | 1 | 10.40 |
| CHEMBL62265 | — | — | 1 | 10.14 |
| CHEMBL65061 | LEUKOTRIENE_B4 | — | 1 | 9.92 |
| CHEMBL262231 | — | — | 1 | 9.85 |
| CHEMBL292783 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292782 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL62265 | — | Ki | = | 0.073 | nM | 10.14 |
| CHEMBL65061 | LEUKOTRIENE_B4 | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL262231 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL292783 | — | Ki | = | 14.0 | nM | 7.85 |