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Assay Detail

CHEMBL709253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against human luteinizing releasing hormone receptor cloned in CHO cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Gonadotropin-releasing hormone receptor (CHEMBL1855)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A.
Randolph JT, Sauer DR, Haviv F, Nilius AM, Greer J.
Bioorg Med Chem Lett (2004) 14 : 1599 -1602
PubMed 15006412 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 8.05 9.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL12282 1 9.48
CHEMBL410940 1 9.07
CHEMBL408925 1 8.89
CHEMBL264043 1 8.82
CHEMBL303274 1 8.73
CHEMBL273275 1 8.41
CHEMBL418067 1 8.14
CHEMBL442482 1 8.12
CHEMBL288534 1 7.88
CHEMBL418256 1 7.73
CHEMBL275467 1 7.73
CHEMBL273387 1 7.65
CHEMBL216252 1 7.56
CHEMBL288396 1 7.10
CHEMBL40743 1 6.72
CHEMBL384920 1 6.69
CHEMBL288216 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL12282 Ki = 0.3311 nM 9.48
CHEMBL410940 Ki = 0.8511 nM 9.07
CHEMBL408925 Ki = 1.288 nM 8.89
CHEMBL264043 Ki = 1.514 nM 8.82
CHEMBL303274 Ki = 1.862 nM 8.73
CHEMBL273275 Ki = 3.89 nM 8.41
CHEMBL418067 Ki = 7.244 nM 8.14
CHEMBL442482 Ki = 7.586 nM 8.12
CHEMBL288534 Ki = 13.18 nM 7.88
CHEMBL418256 Ki = 18.62 nM 7.73
CHEMBL275467 Ki = 18.62 nM 7.73
CHEMBL273387 Ki = 22.39 nM 7.65
CHEMBL216252 Ki = 27.54 nM 7.56
CHEMBL288396 Ki = 79.43 nM 7.10
CHEMBL40743 Ki = 190.55 nM 6.72
CHEMBL384920 Ki = 204.17 nM 6.69
CHEMBL288216 Ki ~ 100000000000000.0 nM -