Assay Detail
Binding
CHEMBL709707
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Compound was evaluated for the time-dependence inhibition of MAO-B at 30 minutes pre-incubation periods
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.35 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17092 | — | — | 1 | 8.66 |
| CHEMBL16781 | — | — | 1 | 8.36 |
| CHEMBL17079 | — | — | 1 | 8.33 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17092 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL16781 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL17079 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL972 | SELEGILINE | IC50 | = | 9.4 | nM | 8.03 |