Assay Detail
Functional
CHEMBL709776
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Effective concentration of compound required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1 number of experiments = 8
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.43 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350982 | — | — | 1 | 7.38 |
| CHEMBL165369 | — | — | 1 | 5.48 |
| CHEMBL351455 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350982 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL165369 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL351455 | — | IC50 | > | 250000.0 | nM | - |