Assay Detail
Functional
CHEMBL709777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TIBO) derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.80 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.82 |
| CHEMBL162598 | DICYCLOHEXYLCARBODIIMIDE | — | 1 | 6.86 |
| CHEMBL292197 | — | — | 1 | 5.40 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.26 |
| CHEMBL66404 | — | — | 1 | 4.90 |
| CHEMBL1095239 | — | — | 1 | 4.72 |
| CHEMBL165369 | — | — | 1 | 4.66 |
| CHEMBL165720 | — | — | 1 | 4.54 |
| CHEMBL349642 | — | — | 1 | 4.46 |
| CHEMBL165503 | — | — | 1 | 4.43 |
| CHEMBL326446 | — | — | 1 | 4.36 |
| CHEMBL65801 | — | — | 1 | 4.33 |
| CHEMBL165841 | — | — | 1 | 4.30 |
| CHEMBL165921 | — | — | 1 | 4.24 |
| CHEMBL351957 | — | — | 1 | 4.21 |
| CHEMBL353986 | — | — | 1 | 4.18 |
| CHEMBL348795 | — | — | 1 | 4.16 |
| CHEMBL165660 | — | — | 1 | 4.15 |
| CHEMBL66377 | — | — | 1 | 4.05 |
| CHEMBL163357 | — | — | 1 | 4.00 |
| CHEMBL421846 | — | — | 1 | - |
| CHEMBL165302 | — | — | 1 | - |
| CHEMBL165248 | — | — | 1 | - |
| CHEMBL164732 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL162598 | DICYCLOHEXYLCARBODIIMIDE | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL292197 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1460 | DIDANOSINE | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL66404 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1095239 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL165369 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL165720 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL349642 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL165503 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL326446 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL65801 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL165841 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL165921 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL351957 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL353986 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL348795 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL165660 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL66377 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL163357 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL421846 | — | IC50 | = | 106000.0 | nM | - |
| CHEMBL165302 | — | IC50 | = | 580000.0 | nM | - |
| CHEMBL165248 | — | IC50 | = | 855000.0 | nM | - |
| CHEMBL164732 | — | IC50 | = | 122000.0 | nM | - |