Assay Detail
Functional
CHEMBL709794
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Efavirenz resistant HIV-1 (Y181C) induced cytopathicity in MT-4 cells.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Simple, short peptide derivatives of a sulfonylindolecarboxamide (L-737,126) active in vitro against HIV-1 wild type and variants carrying non-nucleoside reverse transcriptase inhibitor resistance mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.16 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126278 | — | — | 1 | 8.30 |
| CHEMBL127012 | — | — | 1 | 8.00 |
| CHEMBL283950 | L-737126 | — | 1 | 7.70 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.60 |
| CHEMBL85059 | — | — | 1 | 7.52 |
| CHEMBL2370619 | — | — | 1 | 7.52 |
| CHEMBL126603 | — | — | 1 | 7.52 |
| CHEMBL127048 | — | — | 1 | 7.30 |
| CHEMBL129797 | — | — | 1 | 7.10 |
| CHEMBL129707 | — | — | 1 | 6.85 |
| CHEMBL2370614 | — | — | 1 | 6.80 |
| CHEMBL338559 | — | — | 1 | 6.75 |
| CHEMBL340564 | — | — | 1 | 6.70 |
| CHEMBL2370613 | — | — | 1 | 6.70 |
| CHEMBL129046 | — | — | 1 | 6.52 |
| CHEMBL443548 | — | — | 1 | 6.44 |
| CHEMBL81097 | — | — | 1 | 6.40 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126278 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL127012 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL283950 | L-737126 | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL85059 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2370619 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL126603 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL127048 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL129797 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL129707 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2370614 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL338559 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL340564 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2370613 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL129046 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL443548 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL81097 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 30000.0 | nM | - |