Assay Detail
Functional
CHEMBL709825
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In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF-7 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel nonsteroidal selective estrogen receptor modulators. Carbon and heteroatom replacement of oxygen in the ethoxypiperidine region of raloxifene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.50 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 11.00 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 9.70 |
| CHEMBL150735 | — | — | 1 | 9.05 |
| CHEMBL150492 | — | — | 1 | 8.70 |
| CHEMBL150970 | — | — | 1 | 8.00 |
| CHEMBL151318 | — | — | 1 | 8.00 |
| CHEMBL423035 | — | — | 1 | 7.52 |
| CHEMBL151400 | — | — | 1 | 6.00 |
| CHEMBL146765 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL150735 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL150492 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL150970 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL151318 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL423035 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL151400 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL146765 | — | IC50 | > | 1000.0 | nM | - |