Assay Detail
Binding
CHEMBL709859
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Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
(E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid and related compounds: high affinity leukotriene B4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.89 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292782 | — | — | 1 | 9.33 |
| CHEMBL95453 | — | — | 1 | 9.00 |
| CHEMBL419948 | — | — | 1 | 8.89 |
| CHEMBL328712 | — | — | 1 | 8.70 |
| CHEMBL422420 | — | — | 1 | 8.40 |
| CHEMBL115658 | — | — | 1 | 8.32 |
| CHEMBL325637 | — | — | 1 | 8.24 |
| CHEMBL422598 | — | — | 1 | 8.15 |
| CHEMBL325773 | — | — | 1 | 8.10 |
| CHEMBL112972 | — | — | 1 | 8.04 |
| CHEMBL112707 | — | — | 1 | 7.81 |
| CHEMBL115040 | — | — | 1 | 7.55 |
| CHEMBL325643 | — | — | 1 | 7.28 |
| CHEMBL115362 | — | — | 1 | 7.10 |
| CHEMBL420488 | — | — | 1 | 6.95 |
| CHEMBL113146 | — | — | 1 | 6.79 |
| CHEMBL326192 | — | — | 1 | 6.78 |
| CHEMBL112169 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292782 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL95453 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL419948 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL328712 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL422420 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL115658 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL325637 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL422598 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL325773 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL112972 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL112707 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL115040 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL325643 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL115362 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL420488 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL113146 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL326192 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL112169 | — | Ki | = | 240.0 | nM | 6.62 |