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Assay Detail

CHEMBL709865

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Leukotriene B4 receptor 1 (CHEMBL3911)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and in vitro profile of 7-substituted quinoline chromanols as novel, non-acidic LTB4 antagonists
Masamune H, Breslow R, Cheng J, Conklyn M, Eggler J, Marfat A, Melvin L, Pillar J, Shirley J, Showell H, Tickner J
Bioorg Med Chem Lett (1995) 5 : 887 -892
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.55 6.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL14823 SC-41390 1 6.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL14823 SC-41390 Ki = 280.0 nM 6.55