Assay Detail
Functional
CHEMBL709895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Intracellular cAMP accumulation in Melanocortin 4 receptor functional assay.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.07 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410168 | — | — | 1 | 8.05 |
| CHEMBL2370964 | — | — | 1 | 7.62 |
| CHEMBL438030 | — | — | 1 | 7.47 |
| CHEMBL2370967 | — | — | 1 | 7.36 |
| CHEMBL2370968 | — | — | 1 | 7.30 |
| CHEMBL2370965 | — | — | 1 | 7.28 |
| CHEMBL263878 | — | — | 1 | 7.08 |
| CHEMBL439128 | — | — | 1 | 6.77 |
| CHEMBL437050 | — | — | 1 | 6.75 |
| CHEMBL438235 | — | — | 1 | 6.70 |
| CHEMBL443590 | — | — | 1 | 6.60 |
| CHEMBL409636 | — | — | 1 | 6.47 |
| CHEMBL427629 | — | — | 1 | 6.44 |
| CHEMBL2370963 | — | — | 1 | - |
| CHEMBL411564 | — | — | 1 | - |
| CHEMBL441760 | — | — | 1 | - |
| CHEMBL409049 | — | — | 1 | - |
| CHEMBL2370966 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410168 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2370964 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL438030 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2370967 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2370968 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2370965 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL263878 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL439128 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL437050 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL438235 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL443590 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL409636 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL427629 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2370963 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL411564 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL441760 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL409049 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2370966 | — | EC50 | > | 10000.0 | nM | - |