Melanocortin receptor 4 · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Melanocortin receptor 4 shows approved-linked disease relevance led by obesity. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P32245. Start with obesity, then reuse UniProt P32245 as the stable protein anchor across project notes and exports.
Start with obesity, then reuse UniProt P32245 as the stable protein anchor across project notes and exports.
Melanocortin receptor 4 shows approved-linked disease relevance led by obesity. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with obesity because it currently carries approved-linked support. Linked drugs include SETMELANOTIDE, SETMELANOTIDE ACETATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMelanocortin receptor 4
Review this target as Melanocortin receptor 4, mapped to UniProt P32245. Sequence length is 332 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Melanocortin receptor 4 as ChEMBL target CHEMBL259, mapped to UniProt P32245. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Melanocortin receptor 4 is the right protein anchor across sources, using UniProt P32245 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why obesity is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Melanocortin receptor 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P32245 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Melanocortin receptor 4 |
| UniProt Accession | P32245 |
| Component Type | Protein |
| Sequence Length | 332 aa |
Melanocortin receptor 4
Review this target as Melanocortin receptor 4, mapped to UniProt P32245. Sequence length is 332 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Melanocortin receptor 4 shows approved-linked disease relevance led by obesity. 5 more disease programs remain visible in the same review block.
Start review with obesity because it currently carries approved-linked support. Linked drugs include SETMELANOTIDE, SETMELANOTIDE ACETATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4798971 | 10.82 | Ki | 0.015 | Preclinical |
| CHEMBL4794168 | 10.8 | Ki | 0.01585 | Preclinical |
| CHEMBL4794121 | 10.78 | Ki | 0.0166 | Preclinical |
| CHEMBL441738 | 10.77 | EC50 | 0.017 | Approved |
| CHEMBL413212 | 10.74 | EC50 | 0.018 | Preclinical |
| CHEMBL428615 | 10.72 | EC50 | 0.019 | Preclinical |
| CHEMBL4777048 | 10.71 | Ki | 0.0195 | Preclinical |
| CHEMBL4793821 | 10.68 | Ki | 0.02089 | Preclinical |
| CHEMBL4788071 | 10.68 | Ki | 0.021 | Preclinical |
| CHEMBL4794990 | 10.59 | Ki | 0.0257 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 175 | 2,139 | 7.2 |
| single protein format | 148 | 530 | 7.3 |
| assay format | 7 | 264 | 7.1 |
| cell membrane format | 6 | 78 | 7.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 217 | 968 | 7.3 |
| assay format | 68 | 395 | 7.3 |
| single protein format | 2 | 0 | — |
| cell membrane format | 1 | 26 | 8.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 12 | 7.5 |