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Compound Detail

CHEMBL2103784

COSYNTROPIN
💊 Approved Drug
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💊 Approved Drug
CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C)C(C)C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2103784
Name COSYNTROPIN
Phase Approved
Structure Type BOTH
InChI Key ZOEFCCMDUURGSE-SQKVDDBVSA-N
Therapeutic ✓ Yes

Known Names

Corticotropin tetracosapeptide Cortrosyn Cosyntropin Cosyntropin acetate Cosyntropin hexaacetate Synacthen Synacthen depot Tetracosactida Tetracosactide Tetracosactide acetate Tetracosactide hexaacetate Tetracosactide hexacetate +2 more
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
14
Known Names
4
Indications
1
Mechanisms

Molecular Properties

2933.5
MW (Da)

Drug Information

Molecule Type Protein
First Approval 1970
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Parenteral

Flags

Natural Product
USAN Stem -pin; -trop-
USAN Year 1968

Extended Properties

Molecular Formula C136H210N40O31S
MW 2933.49

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Melanocortin receptor 2 agonist AGONIST Adrenocorticotropic hormone receptor ✓ ✓

Indications

Spasms, Infantile Glomerulonephritis, Membranous Adrenal Gland Diseases Hypertension

ATC Classification

H01AA02
tetracosactide
Level 1: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
Level 2: PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES

Activity Summary

EC50 1 meas. best 9.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Melanocortin receptor 4
CHEMBL259
 EC50 9.19 9.19 0.7 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Melanocortin receptor 4 EC50 = 0.65 nM 9.19 Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 ... 24517312

Literature References

PubMed DOI Target Context # Activities
191614 10.1021/jm00214a028 Unchecked 2
24517312 10.1021/jm500064t Melanocortin receptor 4 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
191614 10.1021/jm00214a028 Lipid bilayer 1

Data from ChEMBL 36 via Core Engine