Assay Detail
Functional
CHEMBL709896
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Stimulation of adenylate cyclase in HEK293 cells expressing the human MC4R receptor was determined by measuring cAMP accumulation using the RPA559 SPA assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
beta-alanine dipeptides as MC4R agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.44 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339053 | — | — | 1 | 8.44 |
| CHEMBL341982 | — | — | 1 | 7.40 |
| CHEMBL337571 | — | — | 1 | 7.16 |
| CHEMBL337351 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339053 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL341982 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL337571 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL337351 | — | EC50 | = | 170.0 | nM | 6.77 |