Assay Detail
Functional
CHEMBL710018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration was measured against frog skin MCR cells at 10 e-4 10 e-12 M Concentration.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | frog |
| Cell Type | MCR |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.80 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 10.82 |
| CHEMBL263948 | — | — | 1 | 9.82 |
| CHEMBL264190 | — | — | 1 | 6.70 |
| CHEMBL3350355 | — | — | 1 | 5.72 |
| CHEMBL302703 | — | — | 1 | 5.70 |
| CHEMBL419625 | — | — | 1 | 5.38 |
| CHEMBL302782 | — | — | 1 | 5.26 |
| CHEMBL2114996 | — | — | 1 | 5.00 |
| CHEMBL66464 | — | — | 1 | - |
| CHEMBL66066 | — | — | 1 | - |
| CHEMBL66866 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.015 | nM | 10.82 |
| CHEMBL263948 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL264190 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3350355 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL302703 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL419625 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL302782 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2114996 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL66464 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL66066 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL66866 | — | EC50 | > | 100000.0 | nM | - |