Assay Detail
Functional
CHEMBL710045
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Inhibition of Quisqualate-Induced PI Hydrolysis measured in CHO Metabotropic glutamate receptor 1 Expressing Cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.89 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2111944 | — | — | 1 | 6.37 |
| CHEMBL138082 | — | — | 1 | 5.92 |
| CHEMBL434064 | — | — | 1 | 5.85 |
| CHEMBL2111945 | — | — | 1 | 5.82 |
| CHEMBL327783 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2111944 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL138082 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL434064 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2111945 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL327783 | — | IC50 | = | 3400.0 | nM | 5.47 |