Assay Detail
Functional
CHEMBL710180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro extracellular concentration required to reduce cell population to 50% against L1210 leukemia cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.93 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.70 |
| CHEMBL33618 | — | — | 1 | 6.72 |
| CHEMBL34401 | — | — | 1 | 6.55 |
| CHEMBL34683 | — | — | 1 | 6.47 |
| CHEMBL33801 | — | — | 1 | 6.30 |
| CHEMBL33505 | — | — | 1 | 6.24 |
| CHEMBL33564 | — | — | 1 | 5.77 |
| CHEMBL263805 | — | — | 1 | 5.64 |
| CHEMBL33760 | — | — | 1 | 5.38 |
| CHEMBL34388 | — | — | 1 | 5.38 |
| CHEMBL446136 | — | — | 1 | 5.19 |
| CHEMBL33674 | — | — | 1 | 4.57 |
| CHEMBL34393 | — | — | 1 | 4.12 |
| CHEMBL33585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL33618 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL34401 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL34683 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL33801 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL33505 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL33564 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL263805 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL33760 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL34388 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL446136 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL33674 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL34393 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL33585 | — | IC50 | > | 100000.0 | nM | - |