Assay Detail
Functional
CHEMBL710298
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to protect the cell against HIV-1 strain IIIB viral cytopathogenicity by 50% in MT-4 cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.38 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.40 |
| CHEMBL108396 | — | — | 1 | 7.52 |
| CHEMBL440706 | — | — | 1 | 7.35 |
| CHEMBL431868 | — | — | 1 | 7.34 |
| CHEMBL324237 | — | — | 1 | 7.11 |
| CHEMBL107180 | — | — | 1 | 7.11 |
| CHEMBL110625 | — | — | 1 | 6.75 |
| CHEMBL108360 | — | — | 1 | 6.62 |
| CHEMBL108647 | — | — | 1 | 6.62 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.60 |
| CHEMBL108581 | — | — | 1 | 6.58 |
| CHEMBL316773 | — | — | 1 | 6.50 |
| CHEMBL320702 | — | — | 1 | 6.50 |
| CHEMBL107606 | — | — | 1 | 6.43 |
| CHEMBL321980 | — | — | 1 | 6.39 |
| CHEMBL106661 | — | — | 1 | 6.26 |
| CHEMBL321026 | — | — | 1 | 6.17 |
| CHEMBL106204 | — | — | 1 | 5.95 |
| CHEMBL320056 | — | — | 1 | 5.85 |
| CHEMBL107562 | — | — | 1 | 5.35 |
| CHEMBL110328 | — | — | 1 | 5.33 |
| CHEMBL31871 | HEPT | — | 1 | 5.30 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.27 |
| CHEMBL108605 | — | — | 1 | 5.16 |
| CHEMBL108196 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL108396 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL440706 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL431868 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL324237 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL107180 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL110625 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL108360 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL108647 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL108581 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL316773 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL320702 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL107606 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL321980 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL106661 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL321026 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL106204 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL320056 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL107562 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL110328 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL31871 | HEPT | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL1460 | DIDANOSINE | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL108605 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL108196 | — | IC50 | = | 6990.0 | nM | 5.16 |