Assay Detail
Functional
CHEMBL710372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against 100I strain and 103N strain of HIV-I in MT-4 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.38 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.72 |
| CHEMBL70517 | — | — | 1 | 7.43 |
| CHEMBL439757 | — | — | 1 | 7.31 |
| CHEMBL71881 | — | — | 1 | 7.15 |
| CHEMBL72205 | — | — | 1 | 6.86 |
| CHEMBL312764 | — | — | 1 | 6.84 |
| CHEMBL72242 | — | — | 1 | 6.69 |
| CHEMBL72528 | — | — | 1 | 6.55 |
| CHEMBL69890 | — | — | 1 | 6.51 |
| CHEMBL70271 | — | — | 1 | 6.50 |
| CHEMBL71882 | — | — | 1 | 6.46 |
| CHEMBL72335 | — | — | 1 | 6.10 |
| CHEMBL70442 | — | — | 1 | 5.96 |
| CHEMBL309456 | — | — | 1 | 5.62 |
| CHEMBL72652 | — | — | 1 | 5.41 |
| CHEMBL72705 | — | — | 1 | 5.38 |
| CHEMBL70863 | — | — | 1 | 5.32 |
| CHEMBL305803 | — | — | 1 | 5.09 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | - |
| CHEMBL431378 | — | — | 1 | - |
| CHEMBL72713 | — | — | 1 | - |
| CHEMBL307950 | — | — | 1 | - |
| CHEMBL310476 | — | — | 1 | - |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | - |
| CHEMBL309975 | — | — | 1 | - |
| CHEMBL308004 | — | — | 1 | - |
| CHEMBL306169 | — | — | 1 | - |
| CHEMBL70514 | — | — | 1 | - |
| CHEMBL70554 | — | — | 1 | - |
| CHEMBL70976 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL70517 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL439757 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL71881 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL72205 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL312764 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL72242 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL72528 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL69890 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL70271 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL71882 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL72335 | — | IC50 | = | 798.0 | nM | 6.10 |
| CHEMBL70442 | — | IC50 | = | 1086.0 | nM | 5.96 |
| CHEMBL309456 | — | IC50 | = | 2371.0 | nM | 5.62 |
| CHEMBL72652 | — | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL72705 | — | IC50 | = | 4188.0 | nM | 5.38 |
| CHEMBL70863 | — | IC50 | = | 4786.0 | nM | 5.32 |
| CHEMBL305803 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL70663 | DAPIVIRINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL431378 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL72713 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL307950 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL310476 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL223228 | EFAVIRENZ | IC50 | > | 10000.0 | nM | - |
| CHEMBL309975 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL308004 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL306169 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL70514 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL70554 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL70976 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL305641 | — | IC50 | > | 10000.0 | nM | - |