Assay Detail
Functional
CHEMBL710376
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Inhibitory activity against 100I strain of HIV-I in MT-4 cells
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.30 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310476 | — | — | 1 | 8.52 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.48 |
| CHEMBL312764 | — | — | 1 | 8.28 |
| CHEMBL439757 | — | — | 1 | 8.18 |
| CHEMBL70517 | — | — | 1 | 8.15 |
| CHEMBL72205 | — | — | 1 | 8.12 |
| CHEMBL71882 | — | — | 1 | 7.96 |
| CHEMBL431378 | — | — | 1 | 7.92 |
| CHEMBL72713 | — | — | 1 | 7.85 |
| CHEMBL306169 | — | — | 1 | 7.82 |
| CHEMBL72528 | — | — | 1 | 7.80 |
| CHEMBL308004 | — | — | 1 | 7.80 |
| CHEMBL70271 | — | — | 1 | 7.77 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 7.75 |
| CHEMBL305803 | — | — | 1 | 7.66 |
| CHEMBL71881 | — | — | 1 | 7.55 |
| CHEMBL72242 | — | — | 1 | 7.51 |
| CHEMBL70442 | — | — | 1 | 7.47 |
| CHEMBL307950 | — | — | 1 | 7.46 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.40 |
| CHEMBL70863 | — | — | 1 | 7.27 |
| CHEMBL305641 | — | — | 1 | 7.22 |
| CHEMBL74164 | — | — | 1 | 7.20 |
| CHEMBL72335 | — | — | 1 | 7.14 |
| CHEMBL70976 | — | — | 1 | 7.12 |
| CHEMBL69890 | — | — | 1 | 7.04 |
| CHEMBL309456 | — | — | 1 | 6.95 |
| CHEMBL70514 | — | — | 1 | 6.92 |
| CHEMBL72652 | — | — | 1 | 6.76 |
| CHEMBL72705 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310476 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL312764 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL439757 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL70517 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL72205 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL71882 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL431378 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL72713 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL306169 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL308004 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL72528 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL70271 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL70663 | DAPIVIRINE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL305803 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL71881 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL72242 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL70442 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL307950 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL70863 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL305641 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL74164 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL72335 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL70976 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL69890 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL309456 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL70514 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL72652 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL72705 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL309975 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL74239 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL70554 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL307297 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 2512.0 | nM | 5.60 |
| CHEMBL421112 | — | IC50 | = | 96600.0 | nM | 4.01 |
| CHEMBL74226 | — | IC50 | > | 100000.0 | nM | - |