Assay Detail
Functional
CHEMBL710380
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against 103N strain and 181C strain of HIV-I in MT-4 cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.96 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.37 |
| CHEMBL72528 | — | — | 1 | 7.85 |
| CHEMBL439757 | — | — | 1 | 7.60 |
| CHEMBL72242 | — | — | 1 | 7.52 |
| CHEMBL70517 | — | — | 1 | 7.50 |
| CHEMBL70442 | — | — | 1 | 7.43 |
| CHEMBL72205 | — | — | 1 | 7.42 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.40 |
| CHEMBL71881 | — | — | 1 | 7.38 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 7.36 |
| CHEMBL431378 | — | — | 1 | 7.28 |
| CHEMBL312764 | — | — | 1 | 7.16 |
| CHEMBL72335 | — | — | 1 | 7.03 |
| CHEMBL307950 | — | — | 1 | 6.97 |
| CHEMBL310476 | — | — | 1 | 6.88 |
| CHEMBL70271 | — | — | 1 | 6.86 |
| CHEMBL70976 | — | — | 1 | 6.82 |
| CHEMBL308004 | — | — | 1 | 6.79 |
| CHEMBL69890 | — | — | 1 | 6.74 |
| CHEMBL70514 | — | — | 1 | 6.71 |
| CHEMBL309456 | — | — | 1 | 6.66 |
| CHEMBL71882 | — | — | 1 | 6.55 |
| CHEMBL72652 | — | — | 1 | 6.45 |
| CHEMBL70554 | — | — | 1 | 6.40 |
| CHEMBL72705 | — | — | 1 | 6.10 |
| CHEMBL305803 | — | — | 1 | 5.96 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 4.70 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL72528 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL439757 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL72242 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL70517 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL70442 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL72205 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL71881 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL70663 | DAPIVIRINE | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL431378 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL312764 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL72335 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL307950 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL310476 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL70271 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL70976 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL308004 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL69890 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL70514 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL309456 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL71882 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL72652 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL70554 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL72705 | — | IC50 | = | 793.0 | nM | 6.10 |
| CHEMBL305803 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 19953.0 | nM | 4.70 |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 100000.0 | nM | - |