Assay Detail
Binding
CHEMBL710518
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 9.04 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344180 | — | — | 1 | 9.60 |
| CHEMBL343934 | — | — | 1 | 9.38 |
| CHEMBL143515 | — | — | 1 | 9.36 |
| CHEMBL342705 | — | — | 1 | 9.33 |
| CHEMBL341603 | — | — | 1 | 9.25 |
| CHEMBL139757 | — | — | 1 | 9.21 |
| CHEMBL787 | MONTELUKAST | 4.0 | 1 | 9.11 |
| CHEMBL141640 | — | — | 1 | 8.96 |
| CHEMBL141405 | — | — | 1 | 8.77 |
| CHEMBL140381 | — | — | 1 | 8.70 |
| CHEMBL140058 | — | — | 1 | 8.54 |
| CHEMBL348229 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344180 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL343934 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL143515 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL342705 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL341603 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL139757 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL787 | MONTELUKAST | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL141640 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL141405 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL140381 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL140058 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL348229 | — | IC50 | = | 5.0 | nM | 8.30 |