Assay Detail
Functional
CHEMBL710537
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Inhibitory activity against 188L strain of HIV-I in MT-4 cells
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.44 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70517 | — | — | 1 | 8.48 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.34 |
| CHEMBL312764 | — | — | 1 | 8.33 |
| CHEMBL72205 | — | — | 1 | 8.32 |
| CHEMBL72528 | — | — | 1 | 8.24 |
| CHEMBL439757 | — | — | 1 | 8.23 |
| CHEMBL70442 | — | — | 1 | 8.11 |
| CHEMBL72242 | — | — | 1 | 8.08 |
| CHEMBL69890 | — | — | 1 | 8.07 |
| CHEMBL308004 | — | — | 1 | 7.80 |
| CHEMBL431378 | — | — | 1 | 7.75 |
| CHEMBL72335 | — | — | 1 | 7.72 |
| CHEMBL70863 | — | — | 1 | 7.70 |
| CHEMBL71882 | — | — | 1 | 7.57 |
| CHEMBL307950 | — | — | 1 | 7.54 |
| CHEMBL70271 | — | — | 1 | 7.47 |
| CHEMBL71881 | — | — | 1 | 7.38 |
| CHEMBL72652 | — | — | 1 | 7.36 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 7.32 |
| CHEMBL72705 | — | — | 1 | 7.30 |
| CHEMBL305803 | — | — | 1 | 7.26 |
| CHEMBL306169 | — | — | 1 | 7.19 |
| CHEMBL70976 | — | — | 1 | 7.16 |
| CHEMBL74239 | — | — | 1 | 7.15 |
| CHEMBL74164 | — | — | 1 | 7.11 |
| CHEMBL309456 | — | — | 1 | 7.10 |
| CHEMBL305641 | — | — | 1 | 7.07 |
| CHEMBL72713 | — | — | 1 | 7.00 |
| CHEMBL70554 | — | — | 1 | 6.94 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70517 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL312764 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL72205 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL72528 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL439757 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL70442 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL72242 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL69890 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL308004 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL431378 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL72335 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL70863 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL71882 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL307950 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL70271 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL71881 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL72652 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL70663 | DAPIVIRINE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL72705 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL305803 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL306169 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL70976 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL74239 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL74164 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL309456 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL305641 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL72713 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL70554 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL309975 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL307297 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL70514 | — | IC50 | = | 782.0 | nM | 6.11 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 1259.0 | nM | 5.90 |
| CHEMBL74226 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL310476 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL421112 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 100000.0 | nM | - |