Assay Detail
Binding
CHEMBL710585
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Inhibition of gelatinase-B (Matrix metalloprotease-9)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.31 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140152 | — | — | 1 | 9.30 |
| CHEMBL141080 | — | — | 1 | 9.05 |
| CHEMBL140970 | — | — | 1 | 8.72 |
| CHEMBL342210 | — | — | 1 | 8.44 |
| CHEMBL441662 | — | — | 1 | 8.43 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.37 |
| CHEMBL1234370 | — | — | 1 | 5.86 |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140152 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL141080 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL140970 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL342210 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL441662 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1234370 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL75094 | PRINOMASTAT | IC50 | < | 0.4 | nM | - |