Assay Detail
Binding
CHEMBL710594
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Inhibition of MMP-9 (matrix metalloprotease-9, gelatinase B)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.42 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24347 | — | — | 1 | 8.80 |
| CHEMBL283427 | — | — | 1 | 8.57 |
| CHEMBL542068 | — | — | 1 | 7.89 |
| CHEMBL277658 | — | — | 1 | - |
| CHEMBL283429 | — | — | 1 | - |
| CHEMBL23725 | — | — | 1 | - |
| CHEMBL24761 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24347 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL283427 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL542068 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL277658 | — | Ki | < | 1.0 | nM | - |
| CHEMBL283429 | — | Ki | < | 1.0 | nM | - |
| CHEMBL23725 | — | Ki | < | 1.0 | nM | - |
| CHEMBL24761 | — | Ki | < | 1.0 | nM | - |