Assay Detail
Functional
CHEMBL710697
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Activity against HIV-1 in MT-4 cells (in vitro)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.45 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.70 |
| CHEMBL295461 | — | — | 1 | 7.43 |
| CHEMBL3350117 | — | — | 1 | 7.34 |
| CHEMBL49588 | — | — | 1 | 7.24 |
| CHEMBL107184 | — | — | 1 | 7.18 |
| CHEMBL48607 | — | — | 1 | 6.72 |
| CHEMBL48416 | — | — | 1 | 6.70 |
| CHEMBL48644 | — | — | 1 | 6.64 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.19 |
| CHEMBL48229 | — | — | 1 | 5.87 |
| CHEMBL49313 | — | — | 1 | 5.76 |
| CHEMBL300889 | — | — | 1 | 5.45 |
| CHEMBL49371 | — | — | 1 | 4.59 |
| CHEMBL49515 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL295461 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3350117 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL49588 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL107184 | — | EC50 | = | 66.5 | nM | 7.18 |
| CHEMBL48607 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL48416 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL48644 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL991 | STAVUDINE | EC50 | = | 651.0 | nM | 6.19 |
| CHEMBL48229 | — | EC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL49313 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL300889 | — | EC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL49371 | — | EC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL49515 | — | EC50 | = | 28500.0 | nM | 4.54 |