Assay Detail
Functional
CHEMBL710698
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Activity against HIV-2 in MT-4 cells (in vitro)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.15 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.52 |
| CHEMBL49588 | — | — | 1 | 7.20 |
| CHEMBL107184 | — | — | 1 | 7.17 |
| CHEMBL3350117 | — | — | 1 | 6.96 |
| CHEMBL295461 | — | — | 1 | 6.92 |
| CHEMBL48644 | — | — | 1 | 6.42 |
| CHEMBL48607 | — | — | 1 | 6.42 |
| CHEMBL48416 | — | — | 1 | 6.33 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.11 |
| CHEMBL49313 | — | — | 1 | 5.39 |
| CHEMBL48229 | — | — | 1 | 5.17 |
| CHEMBL300889 | — | — | 1 | 4.95 |
| CHEMBL49371 | — | — | 1 | 4.29 |
| CHEMBL49515 | — | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL49588 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL107184 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3350117 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL295461 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL48644 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL48607 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL48416 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL991 | STAVUDINE | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL49313 | — | EC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL48229 | — | EC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL300889 | — | EC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL49371 | — | EC50 | = | 50900.0 | nM | 4.29 |
| CHEMBL49515 | — | EC50 | = | 62500.0 | nM | 4.20 |