Assay Detail
Functional
CHEMBL710703
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Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-1 (IIIa)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chicoric acid analogues as HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.19 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.30 |
| CHEMBL29660 | CHICORIC ACID | — | 1 | 5.77 |
| CHEMBL29369 | — | — | 1 | 5.39 |
| CHEMBL282731 | CICHORIC ACID | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL29660 | CHICORIC ACID | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL29369 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL282731 | CICHORIC ACID | EC50 | = | 5300.0 | nM | 5.28 |