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Assay Detail

CHEMBL710705

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects of HIV-2 (ROD)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MT4
Confidence 1 — Organism
Curated By Intermediate

Target

MT4 (CHEMBL388)
Type CELL-LINE
Organism Homo sapiens

Publication

Chicoric acid analogues as HIV-1 integrase inhibitors.
Lin Z, Neamati N, Zhao H, Kiryu Y, Turpin JA, Aberham C, Strebel K, Kohn K, Witvrouw M, Pannecouque C, Debyser Z, De Clercq E, Rice WG, Pommier Y, Burke TR.
J Med Chem (1999) 42 : 1401 -1414
PubMed 10212126 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 4.68 5.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29660 CHICORIC ACID 1 5.07
CHEMBL30455 1 4.29

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29660 CHICORIC ACID EC50 = 8600.0 nM 5.07
CHEMBL30455 EC50 = 51000.0 nM 4.29