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Assay Detail

CHEMBL710807

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Binding
Inhibitory activity against Matrix metalloprotease-9
ChEMBL ↗
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Matrix metalloproteinase-9 (CHEMBL321) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.
Scozzafava A, Supuran CT.
J Med Chem (2000) 43 : 3677 -3687
PubMed 11020282 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 64 6.83 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL123775 — — 1 9.22
CHEMBL293503 — — 1 9.22
CHEMBL306726 — — 1 9.00
CHEMBL340461 — — 1 8.96
CHEMBL332755 — — 1 8.92
CHEMBL262676 — — 1 8.92
CHEMBL122711 — — 1 8.89
CHEMBL331342 — — 1 8.89
CHEMBL123463 — — 1 8.85
CHEMBL122836 — — 1 8.82
CHEMBL432223 — — 1 8.77
CHEMBL55110 — — 1 8.70
CHEMBL331311 — — 1 8.40
CHEMBL123041 — — 1 8.37
CHEMBL330857 — — 1 8.37
CHEMBL304281 — — 1 8.36
CHEMBL122719 — — 1 8.34
CHEMBL441084 — — 1 8.30
CHEMBL122831 — — 1 8.30
CHEMBL450327 — — 1 7.62
CHEMBL311336 — — 1 7.57
CHEMBL332120 — — 1 7.55
CHEMBL293774 — — 1 7.51
CHEMBL440714 — — 1 7.51
CHEMBL316169 — — 1 7.46
CHEMBL123443 — — 1 7.44
CHEMBL122651 — — 1 7.41
CHEMBL82868 — — 1 7.38
CHEMBL123382 — — 1 7.11
CHEMBL332406 — — 1 7.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL123775 — Ki = 0.6 nM 9.22
CHEMBL293503 — Ki = 0.6 nM 9.22
CHEMBL306726 — Ki = 1.0 nM 9.00
CHEMBL340461 — Ki = 1.1 nM 8.96
CHEMBL332755 — Ki = 1.2 nM 8.92
CHEMBL262676 — Ki = 1.2 nM 8.92
CHEMBL122711 — Ki = 1.3 nM 8.89
CHEMBL331342 — Ki = 1.3 nM 8.89
CHEMBL123463 — Ki = 1.4 nM 8.85
CHEMBL122836 — Ki = 1.5 nM 8.82
CHEMBL432223 — Ki = 1.7 nM 8.77
CHEMBL55110 — Ki = 2.0 nM 8.70
CHEMBL331311 — Ki = 4.0 nM 8.40
CHEMBL330857 — Ki = 4.3 nM 8.37
CHEMBL123041 — Ki = 4.3 nM 8.37
CHEMBL304281 — Ki = 4.4 nM 8.36
CHEMBL122719 — Ki = 4.6 nM 8.34
CHEMBL441084 — Ki = 5.0 nM 8.30
CHEMBL122831 — Ki = 5.0 nM 8.30
CHEMBL450327 — Ki = 24.0 nM 7.62
CHEMBL311336 — Ki = 27.0 nM 7.57
CHEMBL332120 — Ki = 28.0 nM 7.55
CHEMBL293774 — Ki = 31.0 nM 7.51
CHEMBL440714 — Ki = 31.0 nM 7.51
CHEMBL316169 — Ki = 35.0 nM 7.46
CHEMBL123443 — Ki = 36.0 nM 7.44
CHEMBL122651 — Ki = 39.0 nM 7.41
CHEMBL82868 — Ki = 42.0 nM 7.38
CHEMBL123382 — Ki = 78.0 nM 7.11
CHEMBL332406 — Ki = 89.0 nM 7.05
CHEMBL331669 — Ki = 96.0 nM 7.02
CHEMBL333532 — Ki = 100.0 nM 7.00
CHEMBL123167 — Ki = 100.0 nM 7.00
CHEMBL333248 — Ki = 120.0 nM 6.92
CHEMBL332429 — Ki = 121.0 nM 6.92
CHEMBL120049 — Ki = 122.0 nM 6.91
CHEMBL121916 — Ki = 126.0 nM 6.90
CHEMBL332858 — Ki = 125.0 nM 6.90
CHEMBL333896 — Ki = 137.0 nM 6.86
CHEMBL83508 — Ki = 143.0 nM 6.84
CHEMBL122925 — Ki = 1300.0 nM 5.89
CHEMBL332362 — Ki = 1700.0 nM 5.77
CHEMBL122950 — Ki = 9000.0 nM 5.05
CHEMBL123233 — Ki = 10000.0 nM 5.00
CHEMBL122868 — Ki = 12000.0 nM 4.92
CHEMBL121592 — Ki = 13000.0 nM 4.89
CHEMBL331114 — Ki = 13000.0 nM 4.89
CHEMBL121729 — Ki = 14000.0 nM 4.85
CHEMBL122109 — Ki = 21000.0 nM 4.68
CHEMBL332439 — Ki = 21000.0 nM 4.68