Assay Detail
Binding
CHEMBL710813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human matrix metalloprotease-9
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure--activity relationships of azasugar-based MMP/ADAM inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.88 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61193 | — | — | 1 | 10.22 |
| CHEMBL327578 | — | — | 1 | 9.03 |
| CHEMBL90321 | — | — | 1 | 8.32 |
| CHEMBL93620 | — | — | 1 | 8.21 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 7.96 |
| CHEMBL419503 | — | — | 1 | 7.19 |
| CHEMBL90806 | — | — | 1 | 7.09 |
| CHEMBL92767 | — | — | 1 | 6.80 |
| CHEMBL93720 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61193 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL327578 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL90321 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL93620 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL279785 | MARIMASTAT | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL419503 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL90806 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL92767 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL93720 | — | Ki | = | 780.0 | nM | 6.11 |