Assay Detail
Binding
CHEMBL710814
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Inhibition of recombinant human matrix metalloprotease-9 (gelatinase B)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.26 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 7.96 |
| CHEMBL330727 | — | — | 1 | 7.68 |
| CHEMBL317307 | — | — | 1 | 7.33 |
| CHEMBL92767 | — | — | 1 | 6.80 |
| CHEMBL93067 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL330727 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL317307 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL92767 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL93067 | — | Ki | = | 310.0 | nM | 6.51 |