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Assay Detail

CHEMBL710820

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The compound was tested for its binding affinity towards 92 kDa gelatinase (Matrix metalloprotease-9)
ChEMBL ↗
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Matrix metalloproteinase-9 (CHEMBL321) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Matrix metalloproteinase inhibitors: a structure-activity study.
Levy DE, Lapierre F, Liang W, Ye W, Lange CW, Li X, Grobelny D, Casabonne M, Tyrrell D, Holme K, Nadzan A, Galardy RE.
J Med Chem (1998) 41 : 199 -223
PubMed 9457244 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 65 8.37 9.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL71482 — — 1 9.39
CHEMBL68890 — — 1 9.27
CHEMBL70430 — — 1 9.24
CHEMBL19611 ILOMASTAT 2.0 1 9.24
CHEMBL306189 — — 1 9.20
CHEMBL70965 — — 1 9.17
CHEMBL70315 — — 1 9.15
CHEMBL420932 — — 1 9.12
CHEMBL70417 — — 1 9.11
CHEMBL306912 — — 1 9.08
CHEMBL71995 — — 1 9.05
CHEMBL305222 — — 1 9.02
CHEMBL71618 — — 1 9.00
CHEMBL307090 — — 1 8.96
CHEMBL74182 — — 1 8.96
CHEMBL306524 — — 1 8.96
CHEMBL306224 — — 1 8.92
CHEMBL70492 — — 1 8.89
CHEMBL306871 — — 1 8.85
CHEMBL69024 — — 1 8.82
CHEMBL303155 — — 1 8.82
CHEMBL310249 — — 1 8.82
CHEMBL72678 — — 1 8.80
CHEMBL308397 — — 1 8.77
CHEMBL70571 — — 1 8.77
CHEMBL72788 — — 1 8.77
CHEMBL302311 — — 1 8.77
CHEMBL308012 — — 1 8.77
CHEMBL422948 — — 1 8.72
CHEMBL70398 — — 1 8.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL71482 — Ki = 0.41 nM 9.39
CHEMBL68890 — Ki = 0.54 nM 9.27
CHEMBL19611 ILOMASTAT Ki = 0.57 nM 9.24
CHEMBL70430 — Ki = 0.58 nM 9.24
CHEMBL306189 — Ki = 0.63 nM 9.20
CHEMBL70965 — Ki = 0.68 nM 9.17
CHEMBL70315 — Ki = 0.7 nM 9.15
CHEMBL420932 — Ki = 0.76 nM 9.12
CHEMBL70417 — Ki = 0.78 nM 9.11
CHEMBL306912 — Ki = 0.83 nM 9.08
CHEMBL71995 — Ki = 0.9 nM 9.05
CHEMBL305222 — Ki = 0.96 nM 9.02
CHEMBL71618 — Ki = 0.99 nM 9.00
CHEMBL74182 — Ki = 1.1 nM 8.96
CHEMBL307090 — Ki = 1.1 nM 8.96
CHEMBL306524 — Ki = 1.1 nM 8.96
CHEMBL306224 — Ki = 1.2 nM 8.92
CHEMBL70492 — Ki = 1.3 nM 8.89
CHEMBL306871 — Ki = 1.4 nM 8.85
CHEMBL69024 — Ki = 1.5 nM 8.82
CHEMBL303155 — Ki = 1.5 nM 8.82
CHEMBL310249 — Ki = 1.5 nM 8.82
CHEMBL72678 — Ki = 1.6 nM 8.80
CHEMBL308012 — Ki = 1.7 nM 8.77
CHEMBL302311 — Ki = 1.7 nM 8.77
CHEMBL72788 — Ki = 1.7 nM 8.77
CHEMBL308397 — Ki = 1.7 nM 8.77
CHEMBL70571 — Ki = 1.7 nM 8.77
CHEMBL422948 — Ki = 1.9 nM 8.72
CHEMBL70398 — Ki = 2.3 nM 8.64
CHEMBL308228 — Ki = 2.5 nM 8.60
CHEMBL70570 — Ki = 2.5 nM 8.60
CHEMBL69506 — Ki = 2.7 nM 8.57
CHEMBL74175 — Ki = 2.8 nM 8.55
CHEMBL306470 — Ki = 3.0 nM 8.52
CHEMBL72743 — Ki = 3.0 nM 8.52
CHEMBL71800 — Ki = 3.0 nM 8.52
CHEMBL68149 — Ki = 3.5 nM 8.46
CHEMBL70354 — Ki = 3.6 nM 8.44
CHEMBL71071 — Ki = 3.7 nM 8.43
CHEMBL304617 — Ki = 3.8 nM 8.42
CHEMBL305780 — Ki = 4.1 nM 8.39
CHEMBL302368 — Ki = 5.0 nM 8.30
CHEMBL72337 — Ki = 5.3 nM 8.28
CHEMBL70406 — Ki = 6.3 nM 8.20
CHEMBL71630 — Ki = 6.5 nM 8.19
CHEMBL302954 — Ki = 6.9 nM 8.16
CHEMBL71713 — Ki = 7.1 nM 8.15
CHEMBL308429 — Ki = 7.9 nM 8.10
CHEMBL70426 — Ki = 8.7 nM 8.06